The GPU is correctly recognized from xencenter that allows me to assign it to a VM. When I start the VM (that is a Windows 10 64bit) it works for a little while, then one of the CPU jumps to 100% while I see the boot of windows turning without end.
The VM has 4 cores, 8GB ram and the K2200 in passthrough. Surprisingly passing through the Intel HD 530 works like a charm.
In the bios I disabled the 64bit mapping of devices.